Maggie (Hathaway) is an alluring free spirit who wont let anyone - or anything - tie her down. But she meets her match in Jamie (Gyllenhaal), whose relentless and nearly infallible charm serve him well with the ladies and in the cutthroat world of pharmaceutical sales. Maggie and Jamies evolving relationship takes them both by surprise, as they find themselves under the influence of the ultimate drug: love.
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